It is a prescription-based medication with recommended dose being 1,800 mg twice daily on day one, followed by 800 mg twice daily up to day 14
NEW DELHI| As Glenmark Pharmaceuticals launched antiviral drug Favipiravir for the treatment of mild to moderate COVID-19 cases, medical experts cautioned against seeing it as a “magic bullet” to treat the deadly virus but said it will be helpful as it can be orally administered and reduce the viral load on Saturday. The real efficacy would be known in the coming months the experts said.
Glenmark Pharmaceuticals said it has launched antiviral drug Favipiravir, under the brand name FabiFlu, for the treatment of patients with mild to moderate COVID-19 at a price of about Rs 103 per tablet. In a statement it said, FabiFlu is the first oral Favipiravir-approved medication in India for the treatment of COVID-19.
Dr Vikas Maurya, Director, Department of Pulmonology and Sleep Disorders, Fortis Hospital, Shalimar Bagh said, “This drug was already being used in Japan for influenza. They have been using it in COVID-19 patients also. Even China was using it and Russia had also given permission in May to use it. Antiviral drugs like Remdesivir and Favipiravir are not specific to COVID-19 but were being used for influenza.”
He said studies found that there was some benefit of Favipiravir in COVID-19 treatment and that is why it has now been launched in India as well. Dr Maurya said with COVID-19 cases rising, the launching of the drug comes as a relief.
While talking to PTI he said, “It is not a magic bullet as it is not the only thing we have to give. This is not a specific drug made for COVID-19 and has been found to be useful, but how much it will be useful we will have to see. Real efficacy will be known when administered on a large scale.”
Dr Maurya said, “Best thing is that it is an oral drug, while Ramdesiver is an intravenous drug. It (Favipiravir) can be even taken at home. So even if it is giving some benefit, it will be quite useful.”
Noted city-based lung surgeon Dr Arvind Kumar said he does not believe that any of these antiviral drugs like Remdisiver or Favipiravir will be game-changers.
Dr Arvinf Kumar said, “If at all ”game changer” can be used, it is for dexamethasone which has shown a significant reduction in mortality and is available cheaply.” Dr Kumar added, there are so many medications available and Favipiravir will also help some patients.
Glenmark Pharmaceuticals said the Favipiravir drug will be available as a 200 mg tablet at a maximum retail price of Rs 3,500 for a strip of 34 tablets. It is a prescription-based medication with recommended dose being 1,800 mg twice daily on day one, followed by 800 mg twice daily up to day 14.
Glenmark said the tablets are being produced by the company at its Baddi facility in Himachal Pradesh. The drug will be available both through hospitals and the retail channel.
On Friday Mumbai-based firm received the manufacturing and marketing approval from the Drugs Controller General of India (DCGI).
Glenmark Pharmaceuticals Chairman and MD Glenn Saldanha said in the statement, “This approval comes at a time when cases in India are spiralling like never before, putting tremendous pressure on our healthcare system.”
He added the company hopes that the availability of an effective treatment such as FabiFlu will considerably help assuage this pressure, and offer patients in India a much-needed option of timely therapy.
Glenmark said the approval’s restricted use entails responsible medication usage where every patient must have signed informed consent before treatment initiation. Glenmark further added Favipiravir can be used for coronavirus patients with co-morbid conditions such as diabetes and heart disease with mild to moderate COVID-19 symptoms. It offers a rapid reduction in viral load within four days and provides faster symptomatic and radiological improvement. It also said Favipiravir has shown clinical improvement of up to 88 per cent in mild to moderate COVID-19 cases.
Considering the emergency and unmet medical need for COVID-19, the DCGI under the fast-tracked approval process granted domestic firm Glenmark Pharmaceuticals the permission to manufacture and market Favipiravir (200 mg) tablet.
Glenmark pharmaceuticals were the first company in India to initiate phase three clinical trials on Favipiravir for COVID-19 patients in India.
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